Spectra Analysis, Inc. Logo 257 Simarano Drive
Marlborough, MA 01752
Phone: 1.508.281.6232
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Hyphenating Infrared Spectroscopy to Gas & Liquid Chromatography



Vibrational Spectroscopy, Infrared Spectroscopy (mid FTIR) in particular, is widely recognized as a reliable technique for the identification and structural elucidation of organic and inorganic materials.  The DiscovIR couples Infrared Spectroscopy to a Chromatographic system (gas or liquid), and allows analytical chemists and product development scientists to easily analyze and identify each component in a complex mixture. The DiscovIR readily identifies compounds such as controlled substances, polymers, copolymers and can be useful in academia, research and industrial settings.

  Forensic Analysis



DiscovIR how to rapidly and accurately identify unknown substances.

With the DiscovIR-GC, forensic analytical chemists can now perform fast and accurate analysis of controlled and non-controlled substances that are routinely secured by law enforcement personnel. The DiscovIR utilizes the high specificity of Infrared Spectroscopy to easily reduce uncertainty in the identification of isomers, allowing for fast and accurate identification of drugs such as oxycodone, hydrocodone, morphine, MDMA, pseudo-ephedrine, ephedrine, cannabinoids, cocaine and methamphetamines. When compared with Mass Spectrometry, Infrared Spectroscopy is able to readily provide detailed chemical information for differential analysis at a higher level of specificity and discrimination that is unattainable through the sole use of Mass Spectrometry. As a “walk-up” instrument, the DiscovIR-GC is capable of meeting the work flow needs of forensic laboratories through high sample volume automated processing. The DiscovIR also makes use of a spectral database search engine to facilitate rapid, unequivocal identification of sample unknowns against commercially available solid phase IR libraries.

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  Polymer Characterization



DiscovIR the science of polymer characterization.

Polymers are defined by the characteristics of their constituent monomer(s) and their microstructural arrangement. Infrared Spectroscopy coupled with a separation technique like Gel Permeation Chromatography (GPC) or Size Exclusion Chromatography (SEC) is well suited to determine the compositional and structural arrangement of polymers or copolymers. GPC-IR (GPC-FTIR or SEC-IR) instruments such as the DiscovIR are perfectly adapted to the needs of polymer chemists. It is adept at performing a wide range of applications such as formulation, deformulation of proprietary polymer blends, copolymer compositional drift or variation across the full Molecular Weight (MW) distribution, and process upsets. These capabilities make the DiscovIR-GPC a proficient tool for meeting the specific demands of R&D and QA/QC laboratories. In addition, the DiscovIR-GPC is auto-sampler friendly and can function at high temperatures while offering the freedom to choose from many solvents for analysis.

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DiscovIR your excipients again.

Formulation is a major component in the efficacy of a drug. Formulation involves the preparation/mixture of an active pharmaceutical ingredient in/with a physical carrier (i.e., a tablet, spray, inhaler, or syrup) to insure adequate efficacy, delivery, and stability. Heavily used in formulation, polymeric excipients such as copovidone (PVP/VA64) can serve various functions when added to API such as matrix former, binding agent or sustained release agent.


For each excipient, the function is largely dependent on the specific physical properties of the excipient, which are, in turn, determined by excipient microstructure. Therefore, proper formulation requires that excipient microstructure be exact and carefully monitored to ensure quality control, safety, and drug stability.  The hyphenation of liquid chromatography (GPC) and Infrared Spectroscopy (FTIR) can provide pharmaceutical development and formulation groups valuable insight into the excipient structural/physical properties for the development of novel drug carriers. By coupling an infrared detector to a GPC separation system, scientists will gain structural information over the entire MW distribution of the studied excipient/formulation. Additionally, a GPC-FTIR such as the DiscovIR-GPC allows for easy monitoring of possible degradation during scale-up and manufacturing process to create safe process windows.  Further downstream, QA/QC groups can also use the GPC-FTIR as a control tool for routine monitoring of drug formulations and monitor excipient consistency by checking compositional variations over the molecular weight distribution.


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  Food and Agriculture


DiscovIR new flavors and fragrances.


We provide a unique solution to laboratories charged with the analyses of food, oil and other edible products. The DiscovIR product line couples mid FTIR Spectroscopy to Liquid or Gas Chromatography in GC-FTIR and LC-FTIR instruments enabling rapid and accurate identification of all the components of food complex mixtures. In particular, Fat in food or Oil (edible or not) can easily be deconstructed to gain structural information on unsaturation level, chain length, double bond configuration of its fatty acids (or FAME). Flavors and Fragrances can also be separated and identified. Infrared Spectroscopy can differentiate very subtle differences between isomers of position or configuration and identify minor components in a mixture by comparing their spectra against the thousands available in commercial libraries. The DiscovIR product line enables analytical chemists to meet the stringent regulatory and quality assurance requirements for nutritional content and authenticity analysis.

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 General Analytical Needs



DiscovIR this versatile instrument for the analysis of complex mixtures.


The combination of two widely used techniques, Infrared Spectroscopy and Liquid or Gas Chromatography, brings a powerful tool to analytical chemists looking to outfit their lab with a versatile instrument for the analysis of complex mixtures.  Complementing MS systems, Infrared Spectroscopy hyphenated systems give information that cannot be obtained through any other means. The DiscovIR can be used for a variety of analytical applications, from entomology (insect alkaloid analysis) to proteomics (proteins secondary structure characterization) to explosive analysis (field sample analysis).

The potential benefits of FT-IR Spectroscopy coupled with LC or GC Chromatography include:

  • Rapid separation and identification of complex mixtures
  • High sensitivity
  • High specificity of Infrared Spectroscopy, enabling differentiation of structural analogs
  • Solid state Mid-IR spectra, allowing for comparison with commercially available libraries
  • Non-destructive technology
  • No exposure to hazardous chemicals

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